The Winter Hexagon is specifically associated with the northern hemisphere of Earth, and the stars that make it up are, for the most part, only clearly visible from northern latitudes. In the southern hemisphere this would in principle be the Summer Hexagon, though practically speaking only the area around Sirius would be visible to suitably placed southern observers.
This table shows the seven constellations that make up the bulk of the Hexagon's area, and the major stars in each that contribute to its shape. Its southwestern borders also strictly include a small part of Lepus the Hare, and a tiny sliver of Eridanus.
On a galactic scale, the entire Hexagon represents a view outwards from the disc of the Milky Way Galaxy, through its Orion and PerseusArms and out into the vastness of intergalactic space that lies beyond.